FIG. 3.

No difference in impairment of Treg suppression in patients with increased susceptibility to autoimmune disease. (A) AITD alone versus those with AITD and at least one additional autoimmune disease. Percentage proliferation of 20,000 activated Teff cells when cocultured with 10,000 Tregs. A one-tailed Mann–Whitney t test was used to compare the groups. (B) Assessment of Treg function in patients with DS. Percentage proliferation of activated Teff cells when cocultured with various concentrations of Tregs. A 20,000:5000 ratio of Teff to Treg. A one-way ANOVA Bonferonni test was used for multiple group comparisons.