Table 1.
Clinicopathological Characteristics of Cases in the Study
| Age, mean±SD (range), years | 58.8±9.7 (40–76) |
| Sex | |
| Male | 5 (10.4%) |
| Female | 43 (89.6%) |
| pT categorya | |
| 1 | 19 (39.6%) |
| 2 | 7 (14.6%) |
| 3 | 20 (41.7%) |
| 4 | 2 (4.2%) |
| N1 categorya | 27 (56.3%) |
| M1 categorya | 0 (0.0%) |
| Clinical stage | |
| I | 15 (31.3%) |
| II | 3 (6.2%) |
| III | 28 (58.3%) |
| IV | 2 (4.2%) |
| Tumor size, mean±SD (range), mm | 18.9±8.6 (5–45) |
| ≤10 mm | 8 (16.7%) |
| 11–20 mm | 28 (58.3%) |
| >20 mm | 12 (25.0%) |
| Tumor capsule (full/partial) | 12 (25.0%) |
| Capsular invasion | 8 (16.7%) |
| Histopathological variant | |
| Papillary | 28 (58.3%) |
| Follicular | 5 (10.4%) |
| Otherb | 15 (31.2%) |
| Oxyphilic changesc | 18 (37.5%) |
| Tumor multifocality | 7 (14.6%) |
| Intrathyroidal spread | 26 (54.2%) |
| Extrathyroidal extension | 20 (41.7%) |
| Vascular invasion | 19 (39.6%) |
| Intratumoral lymphocytic infiltration | 11 (22.9%) |
| Peritumoral lymphocytic infiltration | 36 (75.0%) |
| Tumor fibrosisd | 31 (64.6%) |
| Concomitant thyroid diseasee | 16 (33.3%) |
Values are n (%) unless otherwise noted.
a
pT (pathologically assessed primary tumor size and extension), N (regional lymph node involvement), and M (distant metastasis) categories are defined according to UICC TNM classification (26).
b
Solid variant, oxyphilic variant and tumors with mixed growth pattern.
c
Includes focal oxyphilic changes and oxyphilic tumors.
d
Only moderate/extensive fibrosis.
e
Includes solitary hyperplastic nodules, multinodular goiter, chronic lymphocytic thyroiditis, Hashimoto's thyroiditis, and follicular adenomas.