Table 2.
Comparison of Incidence Densities of Cancer and Hazard Ratio Between Patients With and Without Graves' Disease by Demographic Characteristics
| |
Graves' disease |
|
|
|||||
|---|---|---|---|---|---|---|---|---|
| |
Without |
With |
|
|
||||
| Event | PY | Ratea | Event | PY | Ratea | IRRb[CI] | Adjusted HRb[CI] | |
| All cancer | 457 | 127,623 | 3.58 | 158 | 32,140 | 4.92 | 1.37 (1.26, 1.49)*** | 1.35 (1.12, 1.62)** |
| Sex | ||||||||
| F | 352 | 99,654 | 3.53 | 123 | 25,172 | 4.89 | 1.38 (1.26, 1.52)*** | 1 (Reference) |
| M | 105 | 27,969 | 3.75 | 35 | 6968 | 5.02 | 1.34 (1.12, 1.59)** | 0.99 (0.82, 1.19) |
| Age | ||||||||
| 20–34 | 30 | 44,891 | 0.67 | 20 | 11,527 | 1.74 | 2.60 (2.24, 3.01)*** | 1 (Reference) |
| 35–49 | 164 | 50,044 | 3.28 | 67 | 12,401 | 5.40 | 1.65 (1.44, 1.88)*** | 4.15 (3.06, 5.64)*** |
| 50–64 | 159 | 24,203 | 6.57 | 44 | 6012 | 7.32 | 1.11 (0.92, 1.35) | 7.39 (5.38, 10.2)*** |
| ≥65 | 104 | 8485 | 12.26 | 27 | 2200 | 12.27 | 1.00 (0.76, 1.32) | 13.4 (9.43, 19.1)*** |
| Diabetes | ||||||||
| No | 388 | 120,323 | 3.22 | 128 | 28,860 | 4.44 | 1.38 (1.26, 1.50)*** | 1 (Reference) |
| Yes | 69 | 7300 | 9.45 | 30 | 3280 | 9.15 | 0.97 (0.74, 1.26) | 1.43(1.12, 1.83)** |
| Hypertension | ||||||||
| No | 327 | 111,504 | 2.93 | 120 | 26,363 | 4.55 | 1.55 (1.42, 1.700*** | 1 (Reference) |
| Yes | 130 | 16,119 | 8.07 | 38 | 5777 | 6.58 | 0.82 (0.66, 1.01) | 0.96 (0.77, 1.19) |
| Hyperlipidemia | ||||||||
| No | 380 | 116,783 | 3.25 | 131 | 28,389 | 4.61 | 1.42 (1.30, 1.55)*** | 1 (Reference) |
| Yes | 77 | 10,839 | 7.10 | 27 | 3751 | 7.20 | 1.01 (0.79, 1.29) | 0.93 (0.73, 1.18) |
a
Incidence rate (per 1000 person-years).
b
Multivariable analysis including sex, age, and comorbidities of diabetes, hypertension, and hyperlipidemia.
*
p<0.05; **p<0.01; ***p<0.001.
PY, person-years; IRR, Incidence rate ratio (per 1000 person-years); CI, confidence interval; HR, hazard ratio.