Table 3.
Site-Specific Incidence Rate Ratio and Hazard Ratios of Cancer Between Patients With and Without Graves' Disease
| |
Graves' disease |
|
|
|||
|---|---|---|---|---|---|---|
| |
Without |
With |
|
|
||
| Cancer (ICD-9-CM code) | Event | Ratea | Event | Ratea | IRR [CI] | Adjusted HRb[CI] |
| Head and neck (140–149) | 22 | 0.17 | 8 | 0.25 | 1.44 (1.30, 1.61)*** | 1.28 (0.56, 2.89) |
| Stomach (151) | 21 | 0.16 | 5 | 0.16 | 0.95 (0.83, 1.07) | 0.94 (0.35, 2.51) |
| Colon (153, 154) | 59 | 0.46 | 9 | 0.28 | 0.61 (0.53, 0.69)*** | 0.61 (0.30, 1.24) |
| Hepatoma (155) | 42 | 0.33 | 13 | 0.40 | 1.23 (1.10, 1.37)** | 1.13 (0.60, 2.12) |
| Lung (162) | 42 | 0.33 | 7 | 0.22 | 0.66 (0.58, 0.75)*** | 0.69 (0.31, 1.54) |
| Breast (174) | 97 | 0.76 | 39 | 1.21 | 1.60 (1.46, 1.75)*** | 1.58 (1.09, 2.30)* |
| Uterus (179, 182) | 15 | 0.12 | 2 | 0.06 | 0.53 (0.45, 0.62)*** | 0.50 (0.11, 2.19) |
| Cervical (180) | 30 | 0.24 | 3 | 0.09 | 0.40 (0.34, 0.47)*** | 0.45 (0.14, 1.47) |
| Ovary (183) | 14 | 0.11 | 0 | 0.00 | — | — |
| Prostate (185) | 5 | 0.04 | 3 | 0.09 | 2.38 (2.14, 2.65)*** | 1.97 (0.45, 8.54) |
| Bladder (188) | 14 | 0.11 | 3 | 0.09 | 0.85 (0.75, 0.97)* | 0.81 (0.23, 2.84) |
| Kidney (189) | 18 | 0.14 | 5 | 0.16 | 1.10 (0.98, 1.24) | 1.00 (0.37, 2.72) |
| Thyroid (193) | 20 | 0.16 | 52 | 1.62 | 10.3 (9.31, 11.5)*** | 10.4 (6.18, 17.4)*** |
| Hematologic (200–208) | 25 | 0.20 | 3 | 0.09 | 0.48 (0.41, 0.56)*** | 0.48 (0.14, 1.59) |
| Others | 33 | 0.26 | 6 | 0.19 | 0.72 (0.63, 0.82)*** | 0.70 (0.29, 1.67) |
a
Incidence rate (per 1000 person-years).
b
Multivariable analysis including sex, age, and comorbidities of diabetes, hypertension, and hyperlipidemia.
*
p<0.05; **p<0.01; ***p<0.001.