Figure 5.

Topically applied rC7 promoted wound closure of human skin. A 0.5 cm² (8 mm diameter punch biopsy) full-thickness excision wound was made in human skin grafted onto the mid-back of 8- to 10-week-old athymic nude mice. The wounds were then treated with topically applied 30 µg rC7 (C7) or vehicle (VE) (n = 5 mice per group). (a) Representative days 0, 5, 7, and 10 wounds are shown. Wound sizes were reduced in wounds treated with rC7 compared with vehicle control at 5, 7, and 10 days after wounding. (b) Mean + SD wound size measurements at days 0, 5, 7, 10, 12, and 14 after wounding (n = 5 mice for each group).