Table 6.

List of genes that were altered in the VTA by alcohol drinking and were also significantly different between naïve alcohol-preferring (P) and –non-preferring (NP) rats

Symbol	Gene Description	Lower/up^a	Higher/down	Higher/up	Lower/down
Abca1	ATP-binding cassette, sub-family A (ABC1), member 1			X
Aif1	allograft inflammatory factor 1	X
B2m	beta-2 microglobulin	X
C1qa	complement component 1, q subcomponent, A chain	X
C3	complement component 3	X
Cd53	Cd53 molecule	X
Celsr2	cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)	X
Chmp1b	chromatin modifying protein 1B		X
Cldn11	claudin 11				X
Coq6	Coenzyme Q6 homolog (yeast)				X
Cry1	cryptochrome 1 (photolyase-like)		X
Ctsl1	cathepsin L1				X
Ctss	cathepsin S	X
Dctd	dCMP deaminase			X
Dcxr	dicarbonyl L-xylulose reductase	X
Eif4ebp1	eukaryotic translation initiation factor 4E binding protein 1	X
Emr1	EGF-like module containing, mucin-like, hormone receptor-like 1	X
Errfi1	ERBB receptor feedback inhibitor 1		X
Fcer1g	Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide	X
Fcgr3a	Fc fragment of IgG, low affinity IIIa, receptor	X
Gamt	guanidinoacetate N-methyltransferase				X
Gpd1	glycerol-3-phosphate dehydrogenase 1 (soluble)		X
Gpr84	G protein-coupled receptor 84	X
Grxcr1	glutaredoxin, cysteine rich 1	X
Hhip	Hedgehog-interacting protein				X
Hist1h2bh	histone cluster 1, H2bh				X
Hist2h2aa3	histone cluster 2, H2aa3				X
Idi1	isopentenyl-diphosphate delta isomerase 1				X
Irf8	Interferon regulatory factor 8	X
Itgb2	integrin, beta 2	X
Klf9	Kruppel-like factor 9		X
Laptm5	lysosomal protein transmembrane 5	X
Mal	mal, T-cell differentiation protein				X
Mtmr2	myotubularin related protein 2		X
Mysm1	myb-like, SWIRM and MPN domains 1				X
Npc2	Niemann-Pick disease, type C2	X
Pald	paladin	X
Pcdh20	protocadherin 20		X
Pex11a	peroxisomal biogenesis factor 11 alpha		X
Plekhf1	pleckstrin homology domain containing, family F (with FYVE domain) member 1		X
Psme1	proteasome (prosome, macropain) activator subunit 1	X
Ptpla	protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a				X
Pycard	PYD and CARD domain containing	X
Qdpr	quinoid dihydropteridine reductase			X
Ralgds	ral guanine nucleotide dissociation stimulator				X
Rcn3	reticulocalbin 3, EF-hand calcium binding domain	X
Sc4mol	sterol-C4-methyl oxidase-like				X
Sc65	synaptonemal complex protein SC65	X
Scarb2	scavenger receptor class B, member 2				X
Scrg1	stimulator of chondrogenesis 1				X
Serpinb9	Serine (or cysteine) peptidase inhibitor, clade B, member 9	X
Sgk1	serum/glucocorticoid regulated kinase 1		X
Slc22a4	solute carrier family 22 (organic cation transporter), member 4	X
Slc29a2	solute carrier family 29 (nucleoside transporters), member 2		X
Slc38a2	solute carrier family 38, member 2		X
Tjap1	tight junction associated protein 1				X
Tmem176a	transmembrane protein 176A	X
Tmem176b	transmembrane protein 176B	X
Tsc22d3	TSC22 domain family, member 3		X
Ube2g1	ubiquitin-conjugating enzyme E2G 1		X
Unc93b1	unc-93 homolog B1 (C. elegans)	X
Zfp189	zinc finger protein 189		X

Lower/up = lower expression levels in P vs. NP and up-regulation of expression in the ethanol vs. water group; Higher/down = higher expression levels in P vs. NP and down-regulation of expression in the ethanol vs. water group; Higher/up = higher expression levels in P vs. NP and up-regulation of expression in the ethanol vs. water group; Lower/down = lower expression levels in P vs. NP and down-regulation of expression in the ethanol vs. water group