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. Author manuscript; available in PMC: 2013 Jul 8.

Published in final edited form as: Free Radic Biol Med. 2010 Jan 20;48(8):1034–1043. doi: 10.1016/j.freeradbiomed.2010.01.020

Breathing frequencies, as recorded bi-weekly from week zero (pre-IR) to week ten (time-point of sacrifice). In comparison to nonirradiated control animals, significantly higher breathing rates were measured in animals which received no treatment after IR (P = 0.0079). Animals, which were irradiated and received MnTE-2-PyP⁵⁺ post-IR displayed significantly lower breathing rates in comparison to the IR-only group. Animals, which received late treatment starting 8 weeks post-IR displayed a trend towards elevated breathing frequencies which was not more seen 5 days after starting of treatment (implantation of pumps at day 5 of week 7; measurement of breathing frequencies five days later at day 3 of week 8).

Breathing frequencies, as recorded bi-weekly from week zero (pre-IR) to week ten (time-point of sacrifice). In comparison to nonirradiated control animals, significantly higher breathing rates were measured in animals which received no treatment after IR (P = 0.0079). Animals, which were irradiated and received MnTE-2-PyP⁵⁺ post-IR displayed significantly lower breathing rates in comparison to the IR-only group. Animals, which received late treatment starting 8 weeks post-IR displayed a trend towards elevated breathing frequencies which was not more seen 5 days after starting of treatment (implantation of pumps at day 5 of week 7; measurement of breathing frequencies five days later at day 3 of week 8).