Table 4.
Age-adjusted and multivariable-adjusted hazard ratios and 95 % confidence intervals for melanoma by BMI
| Characteristics | BMI
|
p value for trend | ||
|---|---|---|---|---|
| 18.5–24.9 | 25.0–29.9 | 30+ | ||
| Melanoma—updated BMIa | ||||
| NHS, age-adjusted | 1.0 | 1.23 (1.03, 1.46) | 0.91 (0.72, 1.15) | 0.84 |
| NHS, multivariate-adjustedb | 1.0 | 1.34 (1.12, 1.60) | 1.06 (0.83, 1.36) | 0.24 |
| HPFS, age-adjusted | 1.0 | 1.02 (0.80, 1.29) | 0.76 (0.50, 1.15 | 0.77 |
| HPFS, multivariate-adjustedb | 1.0 | 1.04 (0.82, 1.33) | 0.75 (0.49, 1.15) | 0.78 |
| Combined, age-adjustedb,c | 1.0 | 1.21 (1.05, 1.40) | 0.85 (0.69, 1.04) | 0.84 |
| Combined, multivariate-adjustedb,c | 1.0 | 1.20 (1.04, 1.38) | 0.91 (0.74, 1.13) | 0.78 |
| Combined no. of cases | 440 | 363 | 122 | |
| Melanoma—BMI 10 years prior to diagnosis | ||||
| NHS, age-adjusted | 1.0 | 1.12 (0.90, 1.39) | 0.80 (0.58, 1.09) | 0.64 |
| NHS, multivariate-adjustedb | 1.0 | 1.19 (0.96, 1.48) | 0.89 (0.65, 1.22) | 0.70 |
| HPFS, age-adjusted | 1.0 | 0.99 (0.70, 1.38) | 0.81 (0.43, 1.49) | 0.71 |
| HPFS, multivariate-adjustedb | 1.0 | 1.04 (0.74, 1.47) | 0.90 (0.48, 1.70) | 0.44 |
| Combined, age-adjustedb,c | 1.0 | 1.14 (0.95, 1.36) | 0.78 (0.59, 1.04) | 0.94 |
| Combined, multivariate-adjustedb,c | 1.0 | 1.13 (0.94, 1.36) | 0.85 (0.64, 1.14) | 0.63 |
| Combined number of cases | 316 | 200 | 60 | |
| Melanoma—baseline BMId | ||||
| NHS, age-adjusted | 1.0 | 1.12 (0.93, 1.34) | 1.14 (0.87, 1.49) | 0.21 |
| NHS, multivariate-adjustedb | 1.0 | 1.16 (0.96, 1.41) | 1.20(0.91, 1.59) | 0.097 |
| HPFS, age-adjusted | 1.0 | 0.93 (0.74, 1.19) | 0.84(0.54, 1.32) | 0.42 |
| HPFS, multivariate-adjustedb | 1.0 | 0.97 (0.76, 1.24) | 0.85(0.53, 1.36) | 0.50 |
| Combined, age-adjustedb,c | 1.0 | 1.17 (1.02, 1.35) | 1.09(0.87, 1.38) | 0.054 |
| Combined, multivariate- adjustedb,c | 1.0 | 1.06 (0.91, 1.24) | 1.05(0.83, 1.34) | 0.46 |
| Combined number of cases | 601 | 282 | 83 | |
a
BMI measured one follow-up cycle prior to the diagnosis of skin cancer
b
Multivariate-adjusted for sunburn reaction, family history of melanoma, number of severe sunburns, number of moles, hair color, sun exposure at different age intervals, UV index at residence at different ages, physical activity (quintiles), and history of cardiovascular diseases, type 2 diabetes and cancer
c
The combined analysis of the two cohorts additionally controlling for gender
d
BMI measured from baseline questionnaire (1976 for NHS, 1986 HPFS)