TABLE 3.

Summary of strongest gene x environment associations with transformed BMI and WHR adjusted for BMI among African-Americans adjusted for age at interview and ancestry.

Nearby Gene	Chr.	Interaction	Position (bp)	MA	MAF	BetaSNP (95% CI)	BetaEnv (95% CI)	BetaIntrxn (95% CI)	P-Value Intrxn
BMI Outcome
LOC645687||PELI2	14	rs7350721-Smoking(years)	55403266	C	0.09	−0.01 (−0.02, −0.01)	−0.15 (−0.22, −0.08)	0.41 (0.25, 0.58	5.97×10−7
LOC347097||PIP5K1B	9	rs7864204-Recreational Physical Activity	70418999	A	0.44	0.005 (0.002, 0.01)	−0.04 (−0.06, −0.02)	−0.04 (−0.06, −0.02)	8.70×10−7
CNTNAP2	7	rs4549702-Dietary Energy	147531949	G	0.40	−0.03 (−0.04, −0.01)	0.02 (0.01, 0.03)	0.02 (0.01, 0.03)	1.41×10−6
LOC100128373||DIO3OS	14	rs8008758-Alcohol Intake	100759798	A	0.25	−0.01 (−0.02, −0.01)	−0.70 (−0.83, −0.57)	0.39 (0.23, 0.55)	2.32×10−6
LOC645687||PELI2	14	rs7350721-Smoking(ever/never)	55403266	C	0.09	−0.01 (−0.02, −0.01)	−0.08 (−0.11, −0.06)	0.02 (0.01, 0.02)	3.90×10−6
WHR Outcome
ITGBL1	13	rs9557704-Dietary Energy	101025496	A	0.13	0.05 (0.03, 0.07)	0.02 (0.02, 0.03)	−0.04 (−0.06, −0.03)	2.15×10−7
MGMT	10	rs11016883-Smoking(ever/never)	131390930	C	0.25	−0.01 (−0.01, −0.003)	0.15 (0.12, 0.17)	0.01 (0.01, 0.02)	8.51×10−7
ZNF385D||LOC728516	3	rs1388551-Recreational Physical Activity	22267575	A	0.17	0.01 (0.001, 0.01)	−0.03 (−0.05, −0.02)	−0.07 (−0.10, −0.04)	1.87×10−6
LOC642340	2	rs16827293-Smoking(years)	150217578	A	0.12	0.01 (0.002, 0.01)	0.52 (0.43, 0.62)	−0.44 (−0.63, −0.25	5.23×10−6
SEPT11	4	rs17002342-Alcohol Intake	78174229	T	0.13	−0.02 (−0.03, −0.01)	−0.30 (−0.45, −0.16)	0.61 (0.34, 0.88)	9.22×10−6

^*Beta_SNP-Beta coefficient for the SNP in the model; Beta_Env-Beta coefficient for the lifestyle factor included in the interaction; Beta_Intrxn-Beta coefficient for the interaction term in the model; CI-Confidence interval; Intrxn-interaction