. Author manuscript; available in PMC: 2013 Jul 8.

Published in final edited form as: Hum Genet. 2012 Nov 29;132(3):323–336. doi: 10.1007/s00439-012-1246-3

TABLE 5.

Summary of strongest associated gene x environment associations (TABLE 3 and 4) by BMI strata

Population	Interaction	BMI Category	N	OR_SNP (95% CI)	OR_Env (95% CI)	OR_Intrxn (95% CI)	P-Value Intrxn
African-Americans	rs7350721- Smoking(years)	<25	1,329	1.00 (Reference)	1.00 (Reference)	1.00 (Reference)	-
		≥25–<30	2,745	0.89 (0.73, 1.09)	0.97 (0.94, 1.01)	1.02 (0.96, 1.10)	0.487
		≥30–<35	2,192	0.74 (0.59, 0.92)	0.95 (0.92, 0.99)	1.12 (1.04, 1.21)	0.002
		≥35	1,937	0.65 (0.50, 0.83)	0.95 (0.92, 0.99)	1.17 (1.07, 1.27)	2.03×10⁻⁴
Hispanics	rs7350721- Smoking(years)	<25	880	1.00 (Reference)	1.00 (Reference)	1.00 (Reference)	-
		≥25–<30	1,355	0.96 (0.82, 1.12)	1.02 (0.96, 1.09)	1.02 (0.95, 1.10)	0.502
		≥30–<35	808	1.07 (0.89, 1.28)	1.03 (0.96, 1.11)	1.02 (0.93, 1.11)	0.726
		=35	441	1.12 (0.91, 1.38)	1.01 (0.92, 1.38)	0.96 (0.86, 1.07)	0.498

African-Americans	rs10133840- Dietary Energy	<25	1,329	1.00 (Reference)	1.00 (Reference)	1.00 (Reference)	-
		≥25–<30	2,745	2.40 (1.11, 5.20)	1.55 (1.11, 5.20)	0.48 (0.25, 0.93)	0.028
		≥30–<35	2,192	1.23 (0.55, 2.71)	2.43 (1.74, 3.37)	0.84 (0.43, 1.64)	0.607
		≥35	1,937	2.24 (0.92, 5.47)	4.76 (3.38, 69.72)	0.50 (0.24, 1.05)	0.066
Hispanics	rs10133840- Dietary Energy	<25	880	1.00 (Reference)	1.00 (Reference)	1.00 (Reference)	-
		≥25–<30	1,355	4.63 (1.90, 11.26)	3.93 (2.50, 6.19)	0.28 (0.13, 0.61)	0.001
		≥30–<35	808	6.36 (2.39, 16.93)	7.73 (4.50, 13.26)	0.20 (0.09, 0.46)	1.74×10⁻⁴
		≥35	441	8.29 (2.25, 30.50)	19.94 (10.30, 38.6)	0.14 (0.05, 0.44)	0.001

OR_SNP-Odds ratio for SNP association in the model; OR_Env-Odds ratio for lifestyle factor in the model; OR_Intrxn-Odds ratio for interaction term in the model; CI-Confidence interval; Intrxn-interaction