TABLE 6.
Summary of strongest gene x environment associations with BMI and WHR adjusted for BMI for random-effects meta-analysis of African-American and Hispanic gene x environment interactions
| Nearby Gene | Chr. | Interaction | Position (bp) | MA | Beta(R) | Q | I2 | P-Value (R) |
|---|---|---|---|---|---|---|---|---|
| BMI Outcome | ||||||||
| RPL15P2||DICER1 | 14 | rs10133840-Dietary Energy | 94480282 | C | −0.01 | 0.70 | 0.00 | 3.81×10−7 |
| SGK1||LOC442261 | 6 | rs1763500-Smoking (years) | 67343218 | C | 0.26 | 0.46 | 0.00 | 1.71×10−6 |
| PA2G4P2||SPTLC3 | 20 | rs1413020-Recreational Physical Activity | 12678042 | G | 0.02 | 0.33 | 0.00 | 3.04×10−6 |
| SPTLC3||LOC100130692 | 20 | rs2144134-Alcohol Intake | 13096152 | G | −0.09 | 0.87 | 0.00 | 3.68×10−6 |
| DCC | 18 | rs11876941-Smoking (ever/never) | 49160029 | A | −0.003 | 0.90 | 0.00 | 4.72×10−6 |
|
| ||||||||
| WHR Outcome | ||||||||
| LOC359819||EEF1B3 | 5 | rs10067755-Smoking (years) | 134602211 | C | −0.12 | 0.45 | 0.00 | 1.64×10−6 |
| POU3F1||LOC400750 | 1 | rs11802770-Smoking (ever/never) | 38494250 | T | 0.01 | 0.57 | 0.00 | 2.90×10−6 |
| DNAJC10||FRZB | 2 | rs10931041-Dietary Energy | 183393807 | A | −0.02 | 0.79 | 0.00 | 9.02×10−6 |
| SLC28A3||NTRK2 | 9 | rs4877280-Recreational Physical Activity | 86376225 | T | 0.04 | 0.85 | 0.00 | 8.52×10−6 |
| MAML2 | 11 | rs11021499-Alcohol Intake | 95631777 | A | −0.39 | 0.48 | 0.00 | 1.86×10−6 |