Table 2.
Baseline characteristics of patients in each histopathological class
| Focal | Crescentic | Mixed | Sclerotic | p value | |
|---|---|---|---|---|---|
| Age (years) |
66.1 ± 11.4 |
66.3 ± 12.5 |
66.7 ± 10.2 |
67.5 ± 8.6 |
n.s. |
| Male/female, n |
24/22 |
15/17 |
10/8 |
5/1 |
n.s. |
| MPO-ANCA, n |
40 |
26 |
15 |
5 |
n.s. |
| PR3-ANCA, n |
3 |
2 |
0 |
0 |
|
| Both negative, n |
3 |
4 |
3 |
1 |
|
| eGFR (ml/min/1.73 m2) |
38.1 (22.5–57.4) |
12.0 (7.1–19.7) |
16.5 (8.7–31.6) |
12.4 (9.8–27.4) |
<0.0001 |
| Serum albumin (g/dl) |
3.4 (2.8–3.7) |
2.7 (2.4–3.3) |
3.1 (2.8–3.7) |
3.8 (3.5–3.9) |
<0.01 |
| Serum CRP (mg/dl) |
4.13 (1.43–9.62) |
4.98 (1.65–14.0) |
1.21 (0.10–3.93) |
0.16 (0.10–1.10) |
<0.001 |
| Proteinuria (g/day) |
0.35 (0.21–0.79) |
1.50 (1.04–2.50) |
1.75 (1.07–2.20) |
1.50 (0.25–3.98) |
<0.0001 |
| Immunosuppressants, yes/no, n |
25/21 |
17/15 |
4/14 |
1/5 |
<0.05 |
| Histopathological findings |
|
|
|
|
|
| Normal glomeruli (%) |
73.2 (60.0–81.6) |
17.9 (10.6–28.0) |
35.4 (22.5–43.8) |
11.3 (0–22.0) |
<0.0001 |
| Crescentic glomeruli (%) |
13.8 (8.9–23.6) |
67.7 (60.0–74.7) |
31.4 (15.6–40.4) |
12.4 (3.3–22.4) |
<0.0001 |
| Globally sclerotic glomeruli (%) | 6.5 (0–13.4) | 3.2 (0–13.1) | 29.3 (19.0–40.4) | 64.5 (54.9–71.1) | <0.0001 |
Data are expressed as mean ± SD or median (interquartile range).
Abbreviations: ns not significant, eGFR estimated glomerular filtration rate, MPO myeloperoxidase, PR3 proteinase-3, CRP C-reactive protein Immunosuppressants were administered after the diagnosis of ANCA-associated glomerulonephritis.
eGFR: focal vs. crescentic***, focal vs. mixed**, focal vs. sclerotic*, Serum albumin: focal vs. crescentic*, crescentic vs. sclerotic**, Serum CRP: focal vs. mixed*, focal vs. sclerotic*, crescentic vs. mixed*, crescentic vs. sclerotic**, Proteinuria: focal vs. crescentic***, focal vs. mixed**, Immunosuppressants: focal vs. mixed*, crescentic vs. mixed*, Normal glomeruli: focal vs. crescentic***, focal vs. mixed***, focal vs. sclerotic***, Sclerotic glomeruli: focal vs. crescentic***, crescentic vs. mixed***, crescentic vs. sclerotic***, Globally sclerotic glomeruli: focal vs. mixed***, focal vs. sclerotic***, crescentic vs. mixed***, crescentic vs. sclerotic***, *p < 0.05, **p < 0.01, ***p < 0.001.