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. Author manuscript; available in PMC: 2014 Jun 1.
Published in final edited form as: Bioorg Med Chem Lett. 2013 Mar 29;23(11):3385–3388. doi: 10.1016/j.bmcl.2013.03.077

Scheme 4.

Scheme 4

Reagents and conditions: (a) 1,3-dichloro-1,1,3,3-tetraisopropyldisiloxane, pyridine, rt, 72%; (b) (Boc)2O, DMAP, THF, rt, 30 h, 51%; (c) Et3N.3HF, THF, rt, 15 h, 55%; (d) phenyl(ethoxy-l-alaninyl)phosphorochloridate, t-BuMgCl, THF, rt, overnight; (e) 80% aq. TFA, rt, 2 h, 33% over two steps.