Figure 4. Localization and density of mast cells in human facial skin as shown by immunohistochemistry and quantitative analysis of stained dermis.
Immunoreactivity for tryptase was observed in erythematous rosacea (ETR, n = 9), papulopustular rosacea (PPR, n = 9), phymatous rosacea (PhR, n = 9),lupus erythematosus (LE; n = 9), and healthy skin (HS, n = 10; bar = 100 μm; a–e). The increase in mast cell density was statistically significant for all subtypes (ETR × 3.98; PPR × 4.41; PhR × 2.54), whereas mast cell density did not increase in LE (*P<0.05, **P<0.01; unfilled circles and triangle represent outliers) (f).