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. Author manuscript; available in PMC: 2013 Jul 8.
Published in final edited form as: Circ J. 2013 Apr 10;77(6):1389–1398. doi: 10.1253/circj.cj-13-0176

Figure 1. Mechanisms of chromatin remodeling.

Figure 1

(Top Panel) DNA can be packaged as heterochromatin (tightly packaged and generally inaccessible to proteins such as transcriptional machinery) or as euchromatin (accessible to transcription). (Middle Panel) Chromatin remodeling proteins can alter DNA methylation or histone PTMs, the combination of which can be recognized by “reader proteins” (purple) to confer chromatin state. (Bottom Panel) Non coding RNAs can interact with these chromatin remodelers to target them to specific loci, leading alternatively to gene activation or silencing.