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. Author manuscript; available in PMC: 2013 Jul 8.
Published in final edited form as: Circ J. 2013 Apr 10;77(6):1389–1398. doi: 10.1253/circj.cj-13-0176

Figure 3. Multiple levels of structural organization regulate gene expression in an interphase nucleus.

Figure 3

(Top) An actively transcribed (green) and repressed (red) segment of DNA occur on distinct regions of the same chromosome, directly regulated by chromatin remodelers and noncoding RNA. (Bottom Left) The higher-order chromatin structure surrounding these segments endows another level of regulation, with the cumulative effect of local modifications of nearby segments and neighboring chromosomes combining to create distinct repressive and activating environments. (Bottom Right) The position of the segments in relation to the global features of the nucleus imparts yet another level of regulation. All three levels regulate each other interdependently.