Figure 5. Temporal change in Total Fertility Rate (TFR) and Kawasaki disease incidence and mean patient age.

KD incidence in children of 0–4 years (b) and crude mean patient age (c) were reconstructed based on the TFR in Japan (a). The reconstruction used a univariate time-series model based on Kawasaki disease data recorded either between 2000 and 2010 or between 1979 and 2010.