Table 3.
Effect of reaction variables on drug loading and percent release
| Formulation code | 5FU loading mg/0.5 g of dry gel |
% release of 5FU up to 24 hrs. |
||
|---|---|---|---|---|
| pH 1.2 | pH 5.8 | pH 7.4 | ||
| PVH-1 |
72.62 |
4.66 |
32.2 |
63.67 |
| PVH-2 |
79.22 |
5.19 |
39.3 |
68.23 |
| PVH-3 |
88.81 |
6.01 |
44.1 |
73.29 |
| PVH-4 |
89.65 |
7.21 |
51.1 |
78.55 |
| PVH-5 |
84.44 |
6.22 |
47.3 |
74.19 |
| PVH-6 |
75.23 |
5.98 |
41.2 |
70.37 |
| PVH-7 |
81.71 |
6.63 |
34.4 |
70.32 |
| PVH-8 |
72.91 |
5.32 |
28.8 |
63.35 |
| PVH-9 | 67.26 | 3.81 | 22.2 | 56.44 |