Table 2.
Compound | 4a | 4b | 4c | 4d | 4e | 4f | 4g | 4h | 4i | 4j | 4k | 4l | Donepezil |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
R |
2-Cl |
3-Cl |
4-Cl |
2-F |
3-F |
4-F |
3-OCH3 |
4-OCH3 |
2-NO2 |
3-NO2 |
4-NO2 |
H |
- |
IC50(μM) | 0.91 ± 0.045 | 85 ± 12 | 26 ± 5 | 23 ± 7 | 74 ± 11 | 42 ± 8 | 5.5 ± 0.7 | 72 ± 9 | 36 ± 5 | 59 ± 6 | 40 ± 4 | 9 ± 2 | 0.14 ± 0.03 |