Table 5.
Clinical features and results of patients with positive first COX-2 inhibitor challenge
| Patient no. | Sex/age | Co-morbid disorders | Culprit drug | Paracetamol intolerance | Type of reaction | Manner of diagnosis |
Reaction to oral COX-2 inhibitor challenges |
|||
|---|---|---|---|---|---|---|---|---|---|---|
|
First |
Second |
|||||||||
| Drug Reaction | Drug Reaction | |||||||||
| 1 |
F/55 |
As |
diclofenac |
no |
U/A/Ana |
PH; repRX |
rofecoxib |
U/D |
nd |
|
| 2 |
M/78 |
NS |
diclofenac |
no |
A/D/Ana |
C |
rofecoxib |
U |
nd |
|
| 3 |
F/65 |
As |
multiple |
no |
U |
PH; repRX |
celecoxib |
U |
rofecoxib |
Neg |
| 4 |
F/55 |
NS |
diclofenac |
no |
U/Ana |
C |
rofecoxib |
A |
celecoxib |
Neg |
| 5 |
F/46 |
NS |
naproxen |
no |
A |
PH |
rofecoxib |
A |
celecoxib |
Neg |
| 6 |
M/36 |
NS |
multiple |
yes |
U/A |
PH; repRX |
celecoxib |
U |
nd |
|
| 7 |
F/35 |
NS |
multiple |
no |
U/A |
C |
etoricoxib |
U/A |
celecoxib |
Neg |
| 8 |
F/51 |
As |
diclofenac |
no |
A/D |
PH; repRX |
celecoxib |
U/An/D/A |
nd |
|
| 9 |
F/56 |
NS |
multiple |
yes |
A |
C, repRX |
celecoxib |
A |
rofecoxib |
Neg |
| 10 |
F/50 |
NS |
naproxen |
no |
U/Ana |
PH; repRX |
celecoxib |
A |
etoricoxib |
Neg |
| 11 |
F/59 |
NS |
naproxen |
no |
U/A |
PH; repRX |
celecoxib |
A |
etoricoxib |
Neg |
| 12 |
F/46 |
NS |
diclofenac |
no |
U/A/D/Ana |
PH |
celecoxib |
A |
etoricoxib |
Neg |
| 13 |
F/62 |
U |
multiple |
yes |
U/A |
PH; repRX |
celecoxib |
U |
nd |
|
|
14 |
M/40 |
U |
ibuprofen |
yes |
U/A |
PH; repRX |
celecoxib |
U/D |
etoricoxib |
U/D |
| 15 |
F/66 |
NS |
diclofenac |
no |
U/A/D/Ana |
PH; repRX |
celecoxib |
U/A |
etoricoxib |
Neg |
| 16 |
F/63 |
NS |
multiple |
no |
U/A/ D |
PH; repRX |
celecoxib |
U/A |
etoricoxib |
Neg |
|
17 |
F/53 |
NS |
diclofenac |
no |
U |
C |
celecoxib |
U/A |
etoricoxib |
U/A/D |
| 18 |
F/46 |
A/U |
multiple |
no |
U/A |
PH; repRX |
celecoxib |
A |
etoricoxib |
Neg |
| 19 | M49 | NS | diclofenac | no | U/A | PH | celecoxib | U/A | etoricoxib | Neg |
Legend: F, female; M, male; NS, none specific; As, asthma; U, urticaria; A, angioedema (without weals); Ana, anaphylactic shock; D, dyspnea; PH, patient history; repRx, repeated reaction to the same drug; C, challenge test; nd, not done; Neg, negative reaction. 2 patients with a positive challenge to a second COX-2 inhibitor are highlighted in bold.