Table 1.
Previous published genome wide association studies considered in the present study
A) Published studies of association with Melanoma | |||||||
Study |
Gene |
SNP |
Allele |
OR |
p-value |
MM association |
|
MacGregor et al. 2011 |
PARP1 |
rs3219090 |
A |
0.82 |
9.5 × 10-7 |
Protective |
|
Barrett et al. 2011 |
ATM |
rs1801516 |
A |
0.79 |
4.80 × 10-7 |
Protective |
|
CASP8 |
rs13016963 |
A |
1.18 |
5.68 × 10-7 |
Risk |
||
MX2 |
rs45430 |
G |
0.85 |
5.60 × 10-7 |
Protective |
||
CCND1 |
rs1485993 |
A |
1.19 |
4.15 × 10-7 |
Risk |
||
Duffy et al. 2010 |
IRF4 |
rs12203592 |
C |
1.15 |
4 × 10-3 |
Protective |
|
B) Previous studies of association with Vitamin D levels | |||||||
|
Published Data |
||||||
[VitD] < 75 nmol/L levels |
[VitD] < 50 nmol/L levels |
||||||
Study |
Gene |
SNP |
Allele |
OR (CI 95%) |
p-value |
OR (CI 95%) |
p-value |
Wang et al. 2011 |
CYP2R1 |
rs10741657 |
A |
1.21 (1.45-1.29) |
9.4 × 10-11 |
1.06 (1.00-1.13) |
0.06 |
|
NADSYN1 |
rs7944926 |
A |
1.21 (1.14-1.29) |
4.1 × 10-10 |
1.21 (1.14-1.29) |
4.7 × 10-9 |
NADSYN1 | rs12785878 | G | - | - | - | - |
[VitD] means concentration of vitamin D on plasma.
OR: Odds Ratio.
The allele referes to the one considered as risk allele in the appropriated studies.