Table 4.
MM associated SNPs with statistically significant associations in any of the three penetrance models analysed
| Gene | SNP | Penetrance model |
Non adjusted |
Adjusted |
|||
|---|---|---|---|---|---|---|---|
| OR (CI 95%) | p-value | OR (CI 95%) | p-value | ||||
|
PARP1 |
rs3219090 |
Codominant |
GG/AG/AA |
0.79 (0.63-0.97) |
0.027 |
0.82 (0.62-1.07) |
0.151 |
| Dominant |
GG/AG + AA |
0.76 (0.57-1.01) |
0.059 |
0.80 (0.56-1.15) |
0.228 |
||
| Recessive |
GG + AG/AA |
0.66 (0.41-1.05) |
0.079 |
0.7 (0.38-1.28) |
0.246 |
||
|
IRF4 |
rs12203592 |
Codominant |
CC/CT/TT |
0.97 (0.74-1.26) |
0.801 |
0.76 (0.53-1.08) |
0.122 |
| Dominant |
CC/CT + TT |
0.83 (0.61- 1.12) |
0.214 |
0.65 (0.44-0.98) |
0.037 |
||
| Recessive |
CC + CT/TT |
6.28 (1.45-27.13) |
0.014 |
4.07 (0.83-20.05) |
0.084 |
||
|
NADSYN1 |
rs12785878 |
Codominant |
TT/GT/GG |
0.84 (0.68-1.04) |
0.106 |
0.83 (0.64-1.08) |
0.165 |
| Dominant |
TT/GT + GG |
0.76 (0.57-1.02) |
0.065 |
0.76 (0.53-1.10) |
0.142 |
||
| Recessive |
TT + GT/GG |
0.89 (0.58-1.35) |
0.575 |
0.84 (0.49-1.44) |
0.522 |
||
| ATM | rs1801516 | Codominant |
GG/AG/AA |
0.83 (0.62-1.11) |
0.203 |
0.88 (0.61-1.28) |
0.504 |
| Dominant |
GG/AG + AA |
0.84 (0.6-1.18) |
0.318 |
0.92 (0.59-1.41) |
0.686 |
||
| Recessive | GG + AG/AA | 0.56 (0.23-1.36) | 0.198 | 0.53 (0.15-1.8) | 0.310 | ||
Bold indicates statistically significant results.
OR (CI 95%) means Odds Ratio and its 95% Confidence Interval.
The results are obtained taking into account three penetrance models: Codominant (major homozygotes versus heterozygotes versus minor homozygotes), Dominant (major homozygotes versus heterozygotes plus minor homozygotes) and Recessive (major homozygotes plus heterozygotes versus minor homozygotes).
Adjusted for eye color, hair color, lentigines and childhood sunburn via multivariate analysis by performing logistic regression.