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Increased migration of LoVo-PlGF cells was due to increasing p38 MAPK activation. (A) Phosphorylation levels of p38, JNK and ERK are shown along with total protein levels of p38, JNK and ERK in LoVo-PlGF and LoVo pcDNA control cells. (B) Inhibition of p38 by chemical inhibitor, SB203580 (20 μM) as well as by siRNA of p38 (30 pmole/ml) (C), decreased the migratory ability of LoVo-PlGF. * indicated as P < 0.05.
