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PlGF correlated with Flt-1 expression in CRC tissue and patients with higher expression of PlGF and Flt-1 had worse prognosis in another CRC cohort. (A, B) higher Flt-1 and PlGF mRNA expressions were observed in stage III-IV disease (advanced disease) compared to stage I-II disease (localized disease). (C) Patients with high Flt-1 and high PlGF expression had shorter survival. (D) Flt-1 expression correlated well with PlGF levels.
