Table 2.
Sex-specific odds ratio and 95% confidence interval for hypertension in relation to alkaline phosphatase levels
|
ALP quartiles |
1 SD increments in ALP | Log ALP | |||||
|---|---|---|---|---|---|---|---|
| Q1 (low) | Q2 | Q3 | Q4 (high) | P for trend | |||
| Men | |||||||
| Number at risk |
205 |
215 |
207 |
208 |
|
|
|
| Number of cases (%) |
118 (58) |
134 (62) |
134 (65) |
128 (62) |
|
|
|
| Age-adjusted OR |
1.00 |
1.26 (0.85 to 1.88) |
1.30 (0.87 to 1.95) |
1.11 (0.75 to 1.66) |
0.590 |
1.00 (0.87 to 1.16) |
1.00 (0.62 to 1.59) |
| Multivariable OR |
1.00 |
1.30 (0.86 to 1.99) |
1.29 (0.84 to 1.99) |
1.16 (0.75 to 1.79) |
0.535 |
0.98 (0.83 to 1.15) |
0.95 (0.56 to 1.59) |
| Women | |||||||
| Number at risk |
465 |
458 |
467 |
456 |
|
|
|
| Number of cases (%) |
186 (40) |
271 (59) |
273 (58) |
305 (67) |
|
|
|
| Age-adjusted OR |
1.00 |
1.33 (0.98 to 1.78) |
1.22 (0.91 to 1.64) |
1.61 (1.19 to 2.17) |
0.006 |
1.21 (1.09 to 1.35) |
1.81 (1.26 to 2.60) |
| Multivariable OR | 1.00 | 1.29 (0.95 to 1.76) | 1.14 (0.84 to 1.55) | 1.49 (1.09 to 2.04) | 0.041 | 1.17 (1.04 to 1.31) | 1.57 (1.07 to 2.33) |
Multivariable odds ratio (OR) adjusted further for age, body mass index, smoking, alcohol intake, diabetes, thyroid disease, serum triglycerides, serum aspartate aminotransferase (AST) , serum γ-glutamyltranspeptidase (γ-GTP) and glomerular filtration rate. Hypertension defined as systolic blood pressure ≥140mmHg and/or diastolic blood pressure ≥90 mmHg and/or use of antihypertensive agents. Serum alkaline phosphatase (ALP) levels for quartiles were <194 U/l, 194 to 228 U/l, 229 to 275 U/l, and >275 U/l for men and <199 U/l, 199 to 240 U/l, 241 to 290 U/l, and >290 U/l for women.