Table 3.
Sex-specific data for hypertension in relation to alkaline phosphatase levels and drinking status
| |
ALP quartiles |
1 SD increments in ALP | Log ALP | ||||
|---|---|---|---|---|---|---|---|
| Q1 (low) | Q2 | Q3 | Q4 (high) | P for trend | |||
| Nondrinker men | |||||||
| Number at risk |
77 |
100 |
112 |
115 |
|
|
|
| Number of cases (%) |
35 (45) |
50 (50) |
69 (62) |
73 (63) |
|
|
|
| Age-adjusted OR |
1.00 |
1.27 (0.69 to 2.34) |
1.91 (1.04 to 3.48) |
1.98 (1.09 to 3.62) |
0.011 |
1.40 (1.10 to 1.79) |
2.96 (1.33 to 6.58) |
| Multivariable OR |
1.00 |
1.37 (0.71 to 2.64) |
1.96 (1.03 to 3.73) |
2.23 (1.16 to 4.28) |
0.009 |
1.46 (1.12 to 1.91) |
3.32 (1.38 to 8.02) |
| Nondrinker women | |||||||
| Number at risk |
390 |
399 |
423 |
412 |
|
|
|
| Number of cases (%) |
162 (42) |
238 (60) |
250 (59) |
277 (67) |
|
|
|
| Age-adjusted OR |
1.00 |
1.34 (0.97 to 1.84) |
1.27 (0.93 to 1.73) |
1.64 (1.19 to 2.27) |
0.006 |
1.22 (1.08 to 1.37) |
1.84 (1.24 to 2.72) |
| Multivariable OR |
1.00 |
1.33 (0.96 to 1.85) |
1.21 (0.87 to 1.67) |
1.58 (1.12 to 2.21) |
0.023 |
1.19 (1.05 to 1.35) |
1.68 (1.11 to 2.55) |
| Drinker men |
|
||||||
| Number at risk |
128 |
115 |
95 |
93 |
|
|
|
| Number of cases (%) |
83 (65) |
84 (73) |
65 (68) |
55 (59) |
|
|
|
| Age-adjusted OR |
1.00 |
1.53 (0.88 to 2.67) |
1.14 (0.64 to 2.02) |
0.76 (0.44 to 1.33) |
0.295 |
0.82 (0.67 to 1.00) |
0.59 (0.31 to 1.14) |
| Multivariable OR |
1.00 |
1.39 (0.78 to 2.50) |
0.94 (0.51 to 1.73) |
0.62 (0.34 to 1.14) |
0.103 |
0.73 (0.58 to 0.91) |
0.42 (0.20 to 0.89) |
| Drinker women | |||||||
| Number at risk |
75 |
59 |
44 |
44 |
|
|
|
| Number of cases (%) |
24 (32) |
33 (56) |
23 (52) |
28 (64) |
|
|
|
| Age-adjusted OR |
1.00 |
1.17 (0.52 to 2.66) |
0.87 (0.36 to 2.12) |
1.34 (0.54 to 3.28) |
0.711 |
1.16 (0.87 to 1.55) |
1.60 (0.58 to 4.41) |
| Multivariable OR | 1.00 | 0.89 (0.36 to 2.20) | 0.70 (0.26 to 1.87) | 1.14 (0.42 to 3.09) | 0.953 | 1.01 (0.68 to 1.49) | 1.03 (0.30 to 3.50) |
Data presented as odds ratio (95% confidence interval). Multivariable odds ratio (OR) adjusted further for age, body mass index, smoking, alcohol intake, diabetes, thyroid disease, serum triglycerides, serum aspartate aminotransferase (AST), serum γ-glutamyltranspeptidase (γ-GTP) and glomerular filtration rate. Hypertension defined as systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥90 mmHg and/or use of antihypertensive agents. Serum alkaline phosphatase (ALP) levels for quartiles were <194 U/l, 194 to 228 U/l, 229 to 275 U/l, and >275 U/l for men and <199 U/l, 199 to 240 U/l, 241 to 290 U/l, and >290 U/l for women.