Figure 3.

Physiological effects of Klotho inactivation. a | Kl-knockout mice (Kl^−/−) are smaller in size and weight than wild-type littermates, partly as a result of a lack of adipose tissue accumulation. b | Kl-knockout mice (Kl^−/−) are hypoglycaemic *P <0.001 despite having lower insulin concentrations. ^‡P <0.05 than wild-type littermates, indicating that they have increased insulin sensitivity (100 mg/dl glucose = 5.55 mmol/l; 100 pg/ml insulin = 0.02 pmol/l).