Table 2.
Knowledge base grows with additional information to form the specification
| Subject | Predicate | Object |
|---|---|---|
| CT | images | Tumor |
| Volumetry | analyzes | CT |
| <compliant > LongitudinalVolumetry | estimates | TumorSizeChange |
| TumorSizeChange | predicts | CytotoxicTreatmentResponse |
| TyrosineKinaseInhibitor | is | CytotoxicTreatment |
| WellControlledPhaseIIandIII EfficacyStudy | uses | CytotoxicTreatmentResponse |
| CytotoxicTreatment | influences | NonSmallCellLungCancer |
| CT | images | Thorax |
| Thorax | contains | NonSmallCellLungCancer |
| RegulatoryDrugApproval | dependsOn | PrimaryEndpoint |
| WellControlledPhaseIIandIII EfficacyStudy | assess | PrimaryEndpoint |
| CT-Volumetry | is | <putative > SurrogateEndpoint |