Table 9.

Summary of multilevel modeling results of ex vivo production of cytokines in both groups over time (with controlling for confounding factors) of CCT

	Coefficient	SE	p valuea
IL-12 (ln)
Case (reference, control)	0.212	0.246	0.3888
Time
Linear	0.163	0.070	0.0199
Quadratic	−0.190	0.118	0.1074
Interaction effect
Case × time linear	−0.130	0.099	0.1891
Case × time quadratic	−0.235	0.164	0.1519
TNF-a (ln)
Case (reference, control)	0.161	0.163	0.3233
Time
Linear	0.355	0.086	<0.0001
Quadratic	−0.523	0.136	0.0001
Interaction effect
Case × time linear	0.023	0.122	0.8505
Case × time quadratic	0.195	0.173	0.2597
IL-10 (ln)
Case (reference, control)	0.126	0.127	0.3211
Time
Linear	0.233	0.050	<0.0001
Quadratic	−0.306	0.084	0.0003
Interaction effect
Case × time linear	0.079	0.072	0.2726
Case × time quadratic	0.289	0.114	0.0112
IL-6 (ln)
Case (reference, control)	0.231	0.165	0.1615
Time
Linear	0.710	0.091	<0.0001
Quadratic	−1.023	0.146	<0.0001
Interaction effect
Case × time linear	−0.278	0.130	0.0325
Case × time quadratic	0.437	0.188	0.0201
IL-1β (ln)
Case (reference, control)	0.076	0.155	0.6239
Time
Linear	1.021	0.110	<0.0001
Quadratic	−1.336	0.170	<0.0001
Interaction effect
Case × time linear	−0.174	0.156	0.2647
Case × time quadratic	0.586	0.208	0.0048
IL-8 (ln)
Case (reference, control)	0.063	0.143	0.6595
Time
Linear	0.677	0.092	<0.0001
Quadratic	−1.003	0.143	<0.0001
Interaction effect
Case × time linear	−0.122	0.131	0.3517
Case × time quadratic	0.487	0.175	0.0054

^aAdjusted for GDS (high vs. low), education level (no schooling or primary school vs. secondary school or above), PA duration (≤180 or 181–360 vs. 361+ min), stress level (high vs. low), T_MPSS, smoking status (yes vs. no), BMI, and albumin level