Fig. 1.

[^99mTc]Tilmanocept is composed of a dextran backbone (black) to which are attached multiple units of mannose (green) and DTPA (blue). The mannose units provide a molecular mechanism by which [^99mTc]tilmanocept avidly binds to a receptor specific to recticuloendothelial cells (CD206), and the DTPA units provide a highly stable means to radiolabel tilmanocept with technetium-99m (red). The molecular weight of [^99mTc]tilmanocept is approximately 17,000 grams per mole; the molecular diameter is 7.1 nm