Table 1.

Common pathological features in TBI and AD.

Pathology	TBI (clinical and experimental)	AD (human brain and transgenic mouse model)
↑Soluble Aβ and Aβ plaque deposition	Walker et al., 2012; see review Johnson et al., 2010	See review Torres-Aleman, 2008; Perl, 2010
↑Tau-P and NFT's	Tran et al., 2011; Johnson et al., 2012b	See review Torres-Aleman, 2008; Perl, 2010
Neuronal cell loss	Baldwin et al., 1997; Wakade et al., 2010	See review Torres-Aleman, 2008; Perl, 2010
Synapse loss	Wakade et al., 2010; Gao et al., 2011	Reddy and Beal, 2008; see review Arendt, 2009
Dendritic spine loss and remodeling	Gao et al., 2011; Campbell et al., 2012a	Knobloch and Mansuy, 2008; Hudry et al., 2012