Genipin was found to have a time and concentration effect on increasing the tensile modulus (normalized to t = 0 values) of mature bovine patella tendons (left), with a concentration of 0.625% for 12 hours yielding the highest modulus value. In contrast, no clear trend was observed for genipin cross-linking of human patella tendons (right), with the highest modulus achieved with 0.250% genipin for 6 hours incubation. *p < 0.05 from t = 0 values, ^ p < 0.05 from previous time point, †p < 0.05 from respective 0.250% genipin group.