Table 1.
Putative and known polyketide synthase (PKSs), nonribosomal peptide synthetase (NRPSs) and hybrid PKS-NRPSs analyzed in this study and identified by their accession numbers.
| Mycotoxin | Code | Fungal species | PKS | NRPS | Hybrid PKS-NRPS |
|---|---|---|---|---|---|
| AFLATOXIN | PksA | Aspergillus nomius | Q5VD79 | ||
| AFLATOXIN | PksA | Aspergillus flavus | AAS89999 | ||
| AFLATOXIN | PksL1 | Aspergillus oryzae | BAC45240 | ||
| AFLATOXIN | PksL1 | Aspergillus sojae | AAU08792 | ||
| AFLATOXIN | PksL1 | Aspergillus parasiticus | AAC41675 | ||
| AF-TOXIN | AFT9-1 | Alternaria alternata | BAD97694 | ||
| ALTERNARIOL | PksJ | Alternaria alternata | AFN68301 | ||
| ALTERNARIOL | PksH | Alternaria alternata | AFN68299 | ||
| BEAUVERICIN | BEAS | Beauveria bassiana | ACI30655 | ||
| BEAUVERICIN | putative | Fusarium oxysporum | EGU75688 | ||
| BIKAVERIN | Pks4 | Gibberella fujikuroi | CAB92399 | ||
| CERCOSPORIN | Cercospora nicotianae | AAT69682 | |||
| CERCOSPORIN | CTB1 | Cercospora coffeicola | ADO14690 | ||
| CITRININ | PksCT | Monascus purpureus | AAY33862 | ||
| CITRININ | Trichophyton tonsurans | EGD97507 | |||
| CITRININ | Coccidioides immitis | EJB11047 | |||
| CITRININ | putative | Aspergillus fumigatus | XP_746971 | ||
| CITRININ | putative | Neosartorya fischeri | EAW17018 | ||
| CYCLOPIAZONIC ACID | CpaA | Aspergillus flavus | BAI43678 | ||
| CYCLOPIAZONIC ACID | CpaA | Aspergillus oryzae | BAG82673 | ||
| CHETOGLOBOSIN A | CheA | Penicillium expansum | CAO91861 | ||
| CYTOCHALASIN E | CcsA | Aspergillus clavatus | XM_001270542 | ||
| DOTHISTROMIN | PksA | Mycosphaerella pini | AAZ95017 | ||
| ENNIATIN | Esyn1 | Fusarium equiseti | CAA79245 | ||
| ENNIATIN | Fusarium verticillioides | FVEG_09993 | |||
| EQUISETIN | EqiS | Fusarium heterosporum | Q5SBL2 | ||
| ERGOT ALKALOIDS | CPPS1 | Claviceps purpurea | CAB39315 | ||
| ERGOT ALKALOIDS | CPPS2 | Claviceps purpurea | AJ439610 | ||
| ERGOT ALKALOIDS | CPPS3 | Claviceps purpurea | AJ884677 | ||
| ERGOT ALKALOIDS | CPPS4 | Claviceps purpurea | AJ884678 | ||
| FUMONISIN | FUM1 | Fusarium oxysporum | ACB12550 | ||
| FUMONISIN | FUM1 | Gibberella moniliformis | AF155773 | ||
| FUMONISIN | FUM1-like | Aspergillus niger | CAK43811 | ||
| FUMONISIN | putative | Cochliobolus heterostrophus | AAR90266 | ||
| FUMONISIN | FUM10 | Fusarium oxysporum | ACB12556 | ||
| FUMONISIN | FUM10- like | Aspergillus niger | XP001389107 | ||
| FUMONISIN | FUM14 | Fusarium oxysporum | ACB12559 | ||
| FUMONISIN | FUM14 | Fusarium verticillioides | AAN74817 | ||
| FUMONISIN | FUM14-like | Aspergillus niger | XP_001389112 | ||
| FUMONISIN | putative | Trichoderma atroviride | EHK44571 | ||
| FUSARIN C | FusA | Fusarium fujikuroi | AFP73394 | ||
| FUSARIN C | FusS | Gibberella moniliformis | AAT28740 | ||
| FUSARIN C | PKS10 | Fusarium pseudograminearum | EKJ71911 | ||
| GLIOTOXIN | GliP | Aspergillus fumigatus | AAW03307 | ||
| GLIOTOXIN | GliP | Neosartorya fischeri | XP_001258083 | ||
| GLIOTOXIN | GliP-like | Aspergillus flavus | XP_002380016 | ||
| GLIOTOXIN | GliP-like | Trichoderma virens | EHK22005 | ||
| GLIOTOXIN | putative | Zymoseptoria tritici | XP_003854720 | ||
| HC TOXIN | HTS1 | Cochliobolus carbonum | AAA33023 | ||
| HC TOXIN | Penicillium digitatum | EKV17246 | |||
| LOVASTATIN | LovF | Aspergillus terreus | AAD34559 | ||
| LOVASTATIN | LovB | Aspergillus terreus | Q9Y8A5 | ||
| LOVASTATIN | Magnaporthe oryzae | EHA58179 | |||
| LOVASTATIN | LovB-like | Aspergillus fumigatus | XP_751268 | ||
| LOVASTATIN | putative | Neosartorya fischeri | XP_001262312 | ||
| LOVASTATIN | putative | Fusarium fujikuroi | CAC44633 | ||
| LOVASTATIN | putative | Aspergillus flavus | XP_002385159 | ||
| LOVASTATIN | putative | Aspergillus clavatus | XP_001270376 | ||
| 6-METHYL SALICILIC AC | AtX | Aspergillus terreus | BAA20102.2 | ||
| 6-METHYL SALICILIC AC | MsaS | Aspergillus clavatus | XP_001273093 | ||
| 6-METHYL SALICILIC AC | 6-MSAS | Penicillium griseofulvum | P22367 | ||
| NAPHTHOPYRONE | At4 | Aspergillus terreus | BAB88689 | ||
| NAPHTHOPYRONE | YWA1 | Arthroderma otae | XP_002842704 | ||
| NAPHTHOPYRONE | PksP/Alb1 | Aspergillus fumigatus | AAC39471 | ||
| NAPHTHOPYRONE | WA | Aspergillus nidulans | Q03149 | ||
| OCHRATOXIN A | otapksPN/otanpsPN | Penicillium nordicum | AAP33839 | AAS98174 | |
| OCHRATOXIN A | Aspergillus ochraceus | AAP32477/AAT92023 | |||
| OCHRATOXIN A | Aspergillus niger | XP_001397313 | CAK42678 | ||
| OCHRATOXIN A | Aspergillus carbonarius | PI73482 * | PI 132610* | ||
| OCHRATOXIN A | Aspergillus carbonarius | CAQ16344 | |||
| OCHRATOXIN A | Aoks1 | Aspergillus westerdijkiae | AY583209 | ||
| OCHRATOXIN A | putative | Penicillium verrucosum | AEN14493 | ||
| OCHRATOXIN A | putative | Aspergillus fumigatus | XP748589 | ||
| OCHRATOXIN A | putative | Aspergillus flavus | XP_002375804 | ||
| OCHRATOXIN A | putative | Neurospora crassa | XP955820 | ||
| OCHRATOXIN A | putative | Gibberella zeae | XP390793 | ||
| PATULIN | Penicillium expansum | DQ084387 | |||
| PENICILLIN | Penicillium chrysogenum | P26046 | |||
| PENICILLIN | AcvA | Aspergillus nidulans | CBF84349 | ||
| PM-TOXIN | PKS1 | Mycosphaerella zeae-maydis | AY495642 | ||
| PSEUROTIN A | PsoA | Aspergillus fumigatus | ABS87601 | ||
| SIDEROPHORE | SidC | Aspergillus fumigatus | EAL91050 | ||
| SIDEROPHORE | SidC | Aspergillus nidulans | CBF89140 | ||
| SIRODESMIN | SirP | Leptospheria maculans | AAS92545 | ||
| STERIGMATOCYSTIN | AflC | Aspergillus ochraceoroseus | ACH72912 | ||
| STERIGMATOCYSTIN | PksST | Aspergillus nidulans | AAA81586 | ||
| T-TOXIN | PKS1 | Cochliobolus heterostrophus | AAB08104 | ||
| T-TOXIN | PKS2 | Cochliobolus heterostrophus | AY495643 | ||
| ZEARALENON | PKS13 | Gibberella zeae | ABB90282 | ||
| ZEARALENON | PKS4 | Gibberella zeae | ABB90283 |