Figure 2.

Inhibition curves of recombinant viruses carrying the capsid gene from four patients’ serum specimens. These patients had been nonresponders in a clinical study evaluating DEB025 in HIV-1/HCV-co-infected patients (Flisiak et al., 2008). For each panel, the average percent inhibition effectuated by various concentrations of DEB025 for the recombinant virus (in blue) and the reference virus (strain NL4-3, in red) are depicted. The antiviral activity of DEB025 was determined in the DeCIPhR assay system as described in the Experimental Section.