Figure 4.

MSA inhibits cell growth and causes cell cycle arrest in human melanoma cells. (a) The MeSeH prodrug MSA inhibits the growth of melanoma cells (SK-Mel 28 and Yusac2) with IC₅₀s of 2–3 µM, while normal human melanocytes are much less sensitive (IC₅₀ = 20 μM) n = 3 for each data point. Treatment of SK-Mel 28 (b) and Yusac2 cells (c) with 15 μM MSA causes the cells to arrest in the G₀/G₁-phase. Numbers above bar graphs indicate % of cells in S-phase. Results are representative of 2 separate experiments.