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MSA decreases levels of secreted proteins in melanoma cells. (a) Treatment of melanoma cells with 15 μM MSA for the indicated times results in decreased SPARC levels in both lysates and medium. Results are representative of 3 experiments with each cell line. (b) A matrix metalloprotease inhibitor (MMPI) increases caspase-3 activation in HTB66 cells treated with MSA, n = 3 for each condition.
