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. 2013 Mar 28;5(4):1081–1097. doi: 10.3390/nu5041081

Table 1.

Reported fish consumption and cardiovascular disease.

Reference Year Primary outcomes
Kromhout et al. [11] (Zutphen Study) 1985 An inverse relationship was observed between fish consumption and coronary artery disease death over 20 years of follow-up.
Burr et al. [12] (DART Study) 1989 Fatty fish intake (≥2–3 times/week) reduced mortality in men after myocardial infarction.
Dolecek [13] (MRFIT Study) 1991 Consumption of small amounts of fish (reported as n-3 fatty acids) associated with reduced risk of coronary heart disease.
Siskovick et al. [14] 1995 Intake of fatty fish (≥1 mean/week) was associated with a 50% reduction in risk of primary cardiac arrest.
Ascherio et al. [15] 1995 No significant relationship was observed between fish intake and risk of coronary disease.
Rodriguez et al. [16] (Honolulu Heart Program) 1996 High fish intake (≥2 times/week) among heavy smokers (>30 cigarettes/day) reduced relative risk of coronary heart disease mortality by half.
Daviglus et al. [17] (Chicago Western Electric Study) 1997 An inverse relationship was observed between fish intake and coronary heart disease, especially non-sudden death from myocardial infarction.
Albert et al. [18] (Physicians Health Study) 1998 Fish intake ≥once weekly associated with reduced sudden cardiac death.
Oomen et al. [19] (Seven Countries Study) 2000 Total fish consumption was not associated to coronary heart disease mortality; fatty fish consumption was associated with reduced coronary heart disease mortality.
Iso et al. [20] (Nurses’ Health Study) 2001 Higher fish consumption (≥1–3 times/month) associated with reduced risk of thrombotic infarction but not related to hemorrhagic stroke.
Yuan et al. [21] 2001 Men consuming ≥200 g of fish/shellfish weekly had reduced risk of fatal MI compared to those consuming <50 g/week; no risk reduction was observed for stroke or ischemic heart disease.
Hu et al. [22] (Nurses’ Health Study) 2002 Higher fish consumption (≥1–3 times/month) associated with reduced coronary heart disease risk among women.
He et al. [23] (Health Professionals Follow Up Study) 2002 Risk of ischemic stroke was significantly lower in men who ate fish 1–3 times/month.
Hu et al. [24] (Nurses’ Health Study) 2003 Higher fish consumption (≥1–3 times/month) associated with reduced coronary heart disease risk among women with diabetes.
Mozaffarian et al. [25] (Cardiovascular Health Study) 2003 Consuming tuna or other broiled or baked fish ≥3 times/week reduced risk of ischemic heart disease death; reported fried fish/fish sandwich intake showed no association.
Osler et al. [26] 2003 Fish intake of ≥1 time/week compared to <2 times/month was not associated with the incidence of coronary heart disease.
Erkkila et al. [27] (Estrogen Replacement and Atherosclerosis Trial) 2004 Consumption of fish (≥2 servings of fish or ≥1 serving of tuna or dark fish weekly) was related to significantly reduced progression of coronary artery stenosis in women with coronary artery disease.
Jarvinen et al. [28] 2006 Higher fish consumption was associated with a decreased risk of coronary heart disease in women while no association was observed with men
Streppel et al. [29] (Zutphen Study) 2008 Intake of fatty fish was associated with reduced risk of sudden coronary death.
Yamagishi et al. [30] 2008 An inverse relationship was observed between fish intake and cardiovascular mortality, especially for heart failure.
De Goede et al. [31] 2010 Fish consumption reduced fatal myocardial infarction and coronary heart disease risk in a dose dependant manner; no association was observed with nonfatal myocardial infarction.