Table 2.

Selenoproteins involved in metastasis.

Selenoproteins	Studies	Cancer/cell	Function	Reference
TXR1	in vitro	mammary endothelial cells	TXR1 inhibition reduces VEGF, cell migration, proliferation and tube formation	[47]
	mice	Lewis lung carcinoma cell	TXR1 inhibition reduces lung metastasis	[56]
	in vitro	Lewis lung carcinoma cell	TXR1 inhibition reduces HGF and OPN	[56]
	clinically	human oral squamous cell carcinoma	correlated with lymph node metastasis and with the clinical stage	[57]
GPX3	in vitro	human prostate cancer cells, PC3, DU145 and LNCaP	GPX3 overexpression reduces cell invasion	[58]
	mice	human prostate cancer cells, PC3 with GPX3 overexpression	GPX3 overexpression reduces primary tumor sizes, eliminates metastasis, and promotes survival	[58]
GPX2	in vitro	human colon adenocarcinoma cell, HT29	inhibit cell migration and invasion	[59]
SBP1	in vitro	human colon cancer cell, HCT116	SBP1 overexpression inhibits cell migration	[60]
	in vitro	human liver cancer cell, SMMC7721	SBP1 reduction increases cell migration and GPX1 activity	[61]
Sep15	mice	murine colon cancer cells, CT26	Sep15 inhibition reduces lung metastasis	[62]