Table 2.
In vitro trypanocidal activity of the active extracts against T. brucei rhodesiense trypomastigotes (STIB 900 strain). Data shown are means of two independent assays, which varied <±50%. SI: selectivity index; ratio of cytotoxic activity on L6 cells to trypanocidal activity. E: hydroalcoholic extract, A: ethyl acetate extract.
| IC50 (µg/mL) | Selectivity index (SI) | |||
|---|---|---|---|---|
| Antitrypanosomal activity | Cytotoxic activity | |||
| Species | Extract | T. brucei rhodesiense | L6 cells | |
| B. bifurcata | E | 29.7 | 76.0 | 2.6 |
| B. bifurcata | A | 0.5 | 6.2 | 12.4 |
| C. jubata | A | 23.3 | 71.5 | 3.1 |
| C. crispus | A | 13.6 | 84.3 | 6.2 |
| D. dichotoma | A | 5.8 | 27.8 | 4.8 |
| D. carnosa | A | 15.3 | 74.0 | 4.8 |
| G. latifolium | A | 20.5 | 62.1 | 3.0 |
| G. gracilis | A | 21.5 | 71.3 | 3.3 |
| G. turuturu | A | 10.8 | 71.2 | 6.6 |
| H. flosculosus | A | 22.4 | 58.7 | 2.6 |
| H. elongata | A | 30.3 | 88.3 | 2.9 |
| M. stellatus | A | 19.5 | 69.1 | 3.5 |
| P. canaliculata | A | 7.8 | 86.7 | 11.1 |
| S. muticum | A | 5.8 | 27.8 | 4.8 |
| Standards | ||||
| Melarsoprol | 0.004 | |||
| Podophyllotoxin | 0.007 | |||