Table 3.
Pharmacokinetic parameters (mean ± SD, n = 7) of PSS after a single intravenous injection of PSS, a single oral gavage of PSS and PSS-NP, respectively.
| Parameters | PSS | PSS-NP | |
|---|---|---|---|
| i.v. | i.g. | i.g. | |
| T1/2 (h) | 3.11 ± 0.62 | 35.96 ± 16.65 | 56.23 ± 17.46 |
| Tmax (h) | - | 0.50 ± 0.00 | 0.50 ± 0.00 |
| Cmax (μg/mL) | 1217.21 ± 361.74 | 22.91 ± 4.67 | 31.70 ± 15.30 |
| Cl (L/(h·kg)) | 0.020 ± 0.0039 | 0.12 ± 0.032 | 0.054 ± 0.028 ∗ |
| Vd (L/kg) | 0.087 ± 0.021 | 5.59 ± 1.96 | 3.86 ± 1.17 |
| MRT (h) | 2.59 ± 0.71 | 55.96 ± 23.30 | 84.67 ± 22.67 |
| AUC0–t (h·μg/mL) | 1315.52 ± 314.33 | 251.22 ± 30.25 | 477.57 ± 169.82 ∗ |
∗ p < 0.05, compared with PSS (i.g.).