Table 2. AUC and peak difference between IDIF and MIF (calculated as 100 × (IDIF−MIF)/IDIF), and linear regression analysis data for all radioligands and methods (scatter plots shown in Supplementary Figure 2).

	Input curves properties		Linear regression analysis
	AUC difference (%)	Peak difference (%)	VT slope	VT intercept	VT R2
[11C]flumazenil
Chen	−17.85±7.675	−26.89±20.86	1.21	−0.17	0.98
Mourik	−19.27±10.62	−44.00±15.95	1.29	−0.45	0.95
PWC	−6.91±14.22	2.03±41.17	1.1	−0.13	0.96
[11C]AZ10419369
Chen	8.63±36.27	−17.02±47.59	1.3	−0.25	0.89
Mourik	−0.77±35.17	−36.68±37.33	1.35	−0.23	0.9
Naganawa	71.50±103.53	183.77±206.95	1.29	−0.21	0.9
PWC	2.29±14.82	7.02±18.35	1.01	−0.02	0.96

AUC, area under the curve; IDIF, image-derived input function; MIF, measured input function; PWC, pairwise correlation.

Bold values highlight the method providing slope and R² closest to one, and intercept closest to zero.