Table 2. Test–retest reproducibility of regional [18F]fallypride binding using Method 2 (3 × 20 minutes).
| Region | Testa | Retesta | Variability %b | ICC | Method 1 versus method 2d |
|---|---|---|---|---|---|
| Sensorimotor striatum | 19.82 (3.04) | 19.70 (2.06) | 6.37 (3.70) | 0.839 | 1.77 (1.13) |
| Associative striatum | 17.55 (2.64) | 17.56 (1.84) | 5.80 (5.91) | 0.837 | 1.66 (0.93) |
| Limbic striatum | 16.94 (3.06) | 16.99 (2.06) | 8.25 (6.97) | 0.802 | 1.56 (0.89) |
| Putamen | 21.27 (3.19) | 21.49 (2.21) | 5.68 (4.86) | 0.857 | 1.69 (0.98) |
| Caudate | 16.62 (3.06) | 16.68 (2.35) | 4.43 (4.43) | 0.946 | 1.72 (0.90) |
| Amygdala | 1.76 (0.42) | 1.75 (0.38) | 4.70 (5.30) | 0.967 | 1.02 (0.74) |
| Thalamus | 1.47 (0.29) | 1.46 (0.23) | 6.60 (7.25) | 0.890 | 1.13 (0.74) |
| Hippocampus | 0.81 (0.21) | 0.79 (0.18) | 7.67 (7.84) | 0.935 | 1.38 (1.11) |
| Inferior temporal gyrus | 0.56 (0.21) | 0.57 (0.20) | 5.28 (9.96) | 0.986 | 2.89 (2.60) |
| Middle temporal gyrus | 0.38 (0.18) | 0.38 (0.17) | 7.94 (10.47) | 0.986 | 3.19 (2.76) |
| Orbitofrontal cortex | 0.21 (0.10) | 0.22 (0.11) | 17.45 (14.23) | 0.915 | 2.70 (2.41) |
| Anterior cingulate gyrus | 0.17 (0.11) | 0.17 (0.09) | 37.35 (54.16) | 0.794 | 14.47 (20.50) |
Abbreviation: ICC, intraclass correlation coefficient.
a
BPND given as mean across subjects (s.d.).
b
Absolute variance given as mean across subjects (s.d.)=(|test−retest|/(test+retest)/2)*100.
d
Given as mean percentage difference between Method 1 and Method 2 test BPND (s.d.)=(|Method1_test−Method2_test|/Method1_test) × *100.