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. 2013 Apr 17;33(7):1115–1126. doi: 10.1038/jcbfm.2013.61

Figure 2.

Figure 2

Calcium uniporter (mCU) modulation (inhibition or enhancement) impacted the resting state spontaneous cortical neuronal activity. Inhibition of mCU activity with Ru360 (dose-1=120 μg/kg; dose-2=240 μg/kg) significantly decreased (A) multiunit (MUA) spiking frequency with no significant effect on (B) local field potential (LFP) amplitude. Significantly different during Ru360 treatment: **P⩽0.05; *P⩽0.01; one-way analysis of variance (ANOVA), post hoc Tukey's HSD test. Enhancement of mCU activity with Kaempferol (dose-1=1 mg/kg; dose-2=2 mg/kg) significantly increased (C) MUA spiking frequency with no significant effect on (D) LFP amplitude. Data represent 30 to 60 measurements across nine animals treated with Ru360 and five animals treated with Kaempferol. Significantly different, **P⩽0.05; one-way ANOVA, post hoc Tukey's HSD test.