Skip to main content
. 2013 Apr 17;33(7):1115–1126. doi: 10.1038/jcbfm.2013.61

Figure 4.

Figure 4

Dose dependent functional magnetic resonance imaging -blood oxygen level dependent (BOLD) responses to whisker stimulation in the (A–D) Ru360 (dose-1=120 μg/kg; dose-2=240 μg/kg) and (E–H) Kaempferol (dose-1=1 mg/kg; dose-2=2 mg/kg) treated rats. Whisker stimulation on the right side led to contralateral somatosensory barrel field activation (S1BF; indicated by arrows). Ru360 in a dose dependent manner significantly decreased (A) BOLD activation volume in typical animals and (B) over all animals whereas Kaempferol in the lower dose increased (E) BOLD activation volume in typical animals and (F) over all animals. (C, G) averaged time course of the whisker stimulation-induced BOLD response from the statistically significant voxels in all animals in the Ru360 and Kaempferol treated groups, (D, H) time averaged BOLD response magnitude from the statistically significant voxels during the 30-second stimulation period from 15 trials over five rats each in the Ru360 and Kaempferol treated groups. Significantly different, **P⩽0.05; *P⩽0.01; one-way ANOVA, post hoc Tukey's HSD test.