Figure 5.

Glycolysis in the central nervous system of FVB/Twitcher (Twi) mice and controls. Twi mice and wild-type (WT) littermates were injected at PND30 and PND40 with [1-¹³C]glucose and [1,2-¹³C]acetate and brain extracts were analyzed by ¹³C and ¹H MRS. Diagrams represent levels of the glycolysis-related metabolites: glucose and lactate. (A, D) Total amount (μmol/g tissue) of these metabolites. (B, E) Amount of label (nmol/g tissue) of the respective metabolite. (C, F) Percent enrichment of the respective label. Data represent the mean±s.e.m., n=6 mice/group. One-way analysis of variance and Fisher's least significant difference post hoc tests, *P⩽0.05, statistically significant from WT. Dotted lines indicate a statistically significant difference between PND30 and PND40.