Figure 7.

Amounts of N-acetylaspartate (NAA), N-acetylaspartyl glutamate (NAAG), and osmolytes in the spinal cord of FVB/Twitcher (Twi) mice and controls. Extracts from spinal cord at PND30 and PND40 were analyzed by ¹H MRS (with the exception of taurine, which was measured by high performance liquid chromatography) to quantify amounts of (A) NAA, (B) NAAG, (C) Myo-inositol and (D) Taurine in Twi mice and wild-type (WT) littermates. Concentrations are expressed as μmol/g tissue. Data represent mean±s.e.m., n=6 mice/group. One-way analysis of variance and Fisher's least significant difference post hoc tests, *P⩽0.05, statistically significant from WT. Dotted lines indicate a statistically significant difference between PND30 and PND40.