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Predominant mutations that drove H3N2 antigenic drifts from 1968 to 2007
| Antigenic drift | Mutation(s) |
|---|---|
| HK68 → EN72 | G144D |
| EN72 → VI75 | S145N-S193D |
| VI75 → TX77 | D53K-E82K |
| TX77 → BA79 | K156E |
| BK79 → SI87 | Y155H-K189R |
| SI87 → BE89 | G135E-N145K-N193S |
| BE89 → BE92 | E135K-K145N-E156K |
| BE92 → WU95 | N145K-G172D |
| WU95 → SY97 | K62E-K156Q-E158K |
| SY97 → FU02 | Q156H |
| FU02 → CA04 | K145N-Y159F |
| CA04 → BR07 | S193F-D225N |
