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. Author manuscript; available in PMC: 2013 Jul 9.
Published in final edited form as: Front Biosci. 2009 Jan 1;14:900–917. doi: 10.2741/3285

Figure 2.

Figure 2

A) Schematic of the papillomavirus Long Control Region (LCR) or Upstream Regulatory Region (URR) and E2 binding sites I-IV. B) The consensus E2 binding site derived from the 122 papillomavirus types were analyzed in this study. The frequency of the preferred base pairs at positions -3 and +3 (flanking percentages) and the occurrence of each pair at positions -3 and +3 is shown in the center (central percentages). DNA sequences within the upstream regulatory region (URR) of the papillomaviruses included in this study (Appendix 2) were analyzed for binding motifs containing the ACCN6GGT sequence. This template excludes binding sites in which there is a substitution in the highly conserved bases that participate in the direct interactions between the E2 protein and the DNA. The European Molecular Biology Open Software Suite package was used to locate motifs within a given sequence (117).