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. Author manuscript; available in PMC: 2013 Jul 9.
Published in final edited form as: J Neurochem. 2008 Nov 29;108(2):430–436. doi: 10.1111/j.1471-4159.2008.05777.x

Fig. 1.

Fig. 1

Neurotoxic effects of CD47 in primary mouse cortical neurons. (a) Exposure to CD47 ligand TSP for 24 h induced a dose-dependent neurotoxic response; (b) Pre-treatment with the CD47 blocking antibody for 1 h reduced TSP-induced cell death; (c) The CD47-specific activating peptide 4N1K induced a similar neurotoxic response; n = 3 independent experiments performed in triplicate by the LDH assay; (d) Cell viability reduced after exposure to TSP (10 μg/mL) and 4N1K (25–100 μg/mL) for 24 h; n = 3 independent experiments performed in triplicate by the MTT assay; *p < 0.05 and **p < 0.01 compared with the control group; ^p < 0.05 compared with TSP-treated group (10 μg/mL).