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Schematic diagram of the Keap1-Nrf2 pathway. (A) Functional domains of Keap1 (top) and Nrf2 (bottom). (B) Cul3 based E3 ubiquitin ligase brings about ubiquitination of the substrate molecule Nrf2 via an adaptor protein, Keap1. Nrf2 is then presented to 26S proteasome for degradation.
